Congenital Myasthenic Syndrome (Discovered in the Old Danish Pointer)
Congenital Myasthenic Syndrome (CMS) is a neuromuscular disorder. Affected dogs suffer from exercise intolerance and collapse after 5-30 minutes of exercise.
Key Signs
Temporary collapse, Paralysis induced by exercise
Age of Onset
0 to 2 yrs
Juvenile onset
Inheritance
Autosomal Recessive
For autosomal recessive disorders, dogs with two copies of the variant are at risk of developing the condition. Dogs with one copy of the variant are considered carriers and are usually not at risk of developing the disorder. However, carriers of some complex variants grouped in this category may be associated with a low risk of developing the disorder. Individuals with one or two copies may pass the disorder-associated variant to their puppies if bred.
Likelihood of the Condition
High likelihood
At risk dogs are highly likely to show signs of this disease in their lifetime.
What to Do
Here’s how to care for a dog with CMS
Partner with your veterinarian to make a plan regarding your dog’s well-being, including any insights provided through genetic testing. If your pet is at risk or is showing signs of this disorder, then the first step is to speak with your veterinarian.
For Veterinarians
Here’s what a vet needs to know about CMS
Initial signs of congenital myasthenic syndrome can be observed in 12 to 16 weeks old puppies. Affected dogs suffer from exercise intolerance and collapse after 5 to 30 minutes of exercise. Before collapsing, affected dogs will start to take shorter and shorter strides and eventually fall down. Affected dogs are able to recover from the transient paralysis after resting for a few minutes, but the signs reappear if the dog continues to run.
The clinical signs can be avoided by limiting exercise to a very short period of time and low intensity. If the dog collapses, allow it to rest and recover and then stop further exercise to prevent further difficulties or collapse.
For Breeders
Planning to breed a dog with this genetic variant?
There are many responsibilities to consider when breeding dogs. Regardless of test results it is important that your dog is in good general health and that you are in a position to care for the puppies if new responsible owners are not found. For first time or novice breeders, advice can be found at most kennel club websites.
This disease is autosomal recessive meaning that two copies of the mutation are needed for disease signs to be shown. A carrier dog with one copy of the CMS mutation can be safely bred with a clear dog with no copies of the CMS mutation. About half of the puppies will have one copy (carriers) and half will have no copies of the CMS mutation. Puppies in a litter which is expected to contain carriers should be tested prior to breeding. Carrier to carrier matings are not advised as the resulting litter may contain affected puppies. Please note: It is possible that disease signs similar to the ones caused by the CMS mutation could develop due to a different genetic or clinical cause.
Technical Details
| Gene | CHAT |
|---|---|
| Variant | G>A |
| Chromosome | 28 |
| Coordinate | 1,484,906 |
All coordinates reference CanFam3.1
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References & Credit
Credit to our scientific colleagues:
Proschowsky, H. F., Flagstad, A., Cirera, S., Joergensen, C. B., & Fredholm, M. (2007). Identification of a mutation in the CHAT gene of Old Danish Pointing Dogs affected with congenital myasthenic syndrome. Journal of Heredity, 98(5), 539–543. View the article
